Figure 1
From: Rare non-coding variants are associated with plasma lipid traits in a founder population
Allele frequencies of variants present in Hutterite genomes. (a) Bar plot of variants binned by maximum reported allele frequency in European databases, stratified by European minor allele frequency (MAF) on the x-axis and shown by Hutterite minor allele frequency within each bar. Variants presented include ~7 million variants discovered in 98 Hutterite whole genome sequences23. Maximum European allele frequencies were calculated from surveys of the Exome Sequencing Project (ESP), Exome Aggregation Consortium (ExAC) and the 1000 genomes project. Rare in European variants (REVs) included in the lipid trait association studies are highlighted with a yellow border in the novel and rare categories. (b) Boxplots of log(MAF) by annotation category for the 660,238 REVs included in the lipid trait association studies. Annotation categories were based on RefSeq.24. Numbers in parenthesis correspond to the number of variants in each annotation class. Black vertical lines correspond to the median and whiskers to the 25th and 75th percentiles.
