Figure 2 | Scientific Reports

Figure 2

From: Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma

Figure 2

Plasma levels of C4d in MPM patients. (A) There were no significant differences between MPM patients and healthy volunteers (HV) or patients with non-malignant pleural disease (NMPD) in their circulating C4d levels (MPM versus HVs: Mann Whitney U test, p = 0.833; MPM versus NMPDs: Mann Whitney U test, p = 0.851). (B) Within the MPM cohort, we found a non-significant tendency for higher C4d levels in non-epithelioid compared to epithelioid subtype (Mann Whitney U test, p = 0.182). (C) Also patients with advanced disease (stage III or IV) had the tendency to have higher circulating C4d plasma levels (Mann Whitney U test, p = 0.079). (D) Comparison of radiologically assessed tumor volumetric data and circulating C4d levels. After dividing the cohort (cut-off 1.5 µg/mL), high C4d levels were significantly associated with a higher tumor load (366.7 ± 72.7 versus 190.3 ± 46.7 cm3, p = 0.047).

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