Figure 4 | Scientific Reports

Figure 4

From: Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma

Figure 4

Circulating plasma level of C4d correlates with chemotherapy response and prognosis in MPM patients. (A) Following induction chemotherapy, patients with partial or major response (PR/MR) had significantly lower circulating C4d values when comparing to patients with stable or progressive disease (SD/PD) (0.52 ± 0.13 versus 2.02 ± 0.42 µg/mL, p = 0.005). (B) Kaplan-Meier survival curve of all MPM patients with plasma samples collected at time of diagnosis (n = 30). After dividing the cohort (cut-off 1.5 µg/mL) into low (n = 21) and high (n = 9) C4d plasma levels, those with low plasma C4d had significantly shorter OS (HR 7.33, CI 1.71–31.44, p = 0.007).

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