Table 1 Patient characteristics, clinicopathological variables and expressions of miR-205 and their associations with biochemical failure in 535 prostate cancer patients (univariate analyses; log-rank test, unadjusted Cox proportional hazard ratios).

Age

0.237

≤65 years

357

67

77

1

>65 years

178

33

70

1.19 (0.89–1.59)

pT-stage

<0.001

pT2

374

70

83

1

pT3a

114

21

61

2.30 (1.67–3.15)

pT3b

47

9

43

4.41 (3.01–6.47)

Preop PSA

<0.001

PSA < 10

308

57

81

1

PSA > 10

221

42

68

1.65 (1.24–2.18)

Missing

6

1

—

ISUP Grade

<0.001

1 (Gleason 3 + 3)

183

34

83

1

2 (Gleason 3 + 4)

219

41

77

1.35 (0.95–1.92)

3 (Gleason 4 + 3)

81

15

70

2.14 (1.41–3.26)

4 (Gleason 4 + 4)

17

4

58

3.14 (1.59–6.19)

5 (Gleason ≥9)

35

6

37

4.30 (2.63–7.03)

Positive surgical margin

0.049

No

249

47

81

1

Yes

286

53

69

1.33 (1.00–1.76)

Apical positive surgical margin

0.063

No

325

61

74

1

Yes

210

39

77

0.76 (0.56–1.02)

Non-apical positive surgical margin

<0.001

No

381

71

82

1

Yes

154

29

57

2.25 (1.69–2.97)

CAPRA-S Score

<0.001

0–2

169

32

88

1

3–5

258

48

78

1.85 (1.25–2.73)

6–12

102

19

46

5.28 (3.51–7.93)

NC due to missing PSA

6

1

—

Tumor size

<0.001

0–20 mm

250

47

83

1

>20 mm

285

53

68

1.79 (1.34–2.39)

Perineural infiltration

<0.001

No

401

75

80

1

Yes

134

25

60

2.16 (1.63–2.88)

Lymphovascular infiltration

<0.001

No

492

92

77

1

Yes

43

8

47

2.26 (1.29–3.41)

Surgical procedure

0.466

Retropubic

435

81

77

1

Perineal

100

19

68

1.14 (0.81–1.60)

miR-205 in epithelium

0.003

Low expression

220

41

81

1

High expression

245

46

78

1.61 (1.18–2.21)

Missing

70

13

—