Table 3 Prognostic factors and their independent associations with biochemical failure in prostate tissue in 535 prostate cancer patients (multivariate analyses; stratified Cox regression with backward conditional model).

Characteristics	Patients		Biochemical failure
	Patients		ISUP Grade 1–2		ISUP Grade 3–5
	(n)	(%)	HR (95% CI)	p	HR (95% CI)	p
pT-stage				NS		<0.001
pT2	374	70			1
pT3a	114	21			2.78 (1.47–5.25)
pT3b	47	9			4.99 (2.66–9.35)
Preop PSA				NS		NS
PSA < 10	308	57
PSA > 10	221	42
Missing	6	1
Positive surgical margin				NS		NS
No	249	47
Yes	286	53
Tumor size				NS		NS
0–20 mm	250	47
>20 mm	285	53
Perineural infiltration				0.003		NS
No	250	47	1
Yes	285	53	1.93 (1.25–2.97)
Lymphovascular infiltration				NS		NS
No	492	92
Yes	43	8
miR-205 in epithelium				0.001		NS
Low expression	220	41	1
High expression	245	46	2.07 (1.37–3.15)
Missing	70	13	—

Abbreviations: HR = hazard ratio; NS = not significant and removed by backward model before last step of analyses.

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