Figure 4
(A) Histology detail of the repaired calvaria after 3 days, 4, 8 and 18 weeks of CHT/GO 3.0 wt.% implantation (a) and (b) 3 days post-implantation; (c) and (d) 4 weeks post-implantation; (e) and (f) 8 weeks post-implantation; (g) and (h) 18 weeks post-implantation; symbols: scaffold (Sc); granulation tissue (GT); fibroconnective tissue (Fc); capillary (red arrow); new bone island (Nb); osteoprogenitor cells infiltration (black arrow); Masson Goldnertrichrome stain. Scale 50 µm. (B) Histomophometric analysis of Masson Goldner trichrome-stained sections showing total bone regeneration in mice calvarial defects implanted with CHT/GO after 18 weeks post-implantation.
