Table 2 Conjunction FDR: Pleiotropic Loci in BMI and T2D (cFDR < 0.05).
From: Novel Common Variants Associated with Obesity and Type 2 Diabetes Detected Using a cFDR Method
RSID | ROLE | GENE | CHR | P.valueA | P.valueB | cFDR.AcB | cFDR.BcA | conjunction FDR |
|---|---|---|---|---|---|---|---|---|
rs9930506 | intronic | FTO | chr16 | 2.52E–124 | 1.90E–10 | 1.01E–123 | 1.90E–10 | 1.90E–10 |
rs10787472 | intronic | TCF7L2 | chr10 | 3.25E–07 | 1.30E–36 | 3.25E–07 | 6.63E–35 | 3.25E–07 |
rs2881654 | intronic | PPARG | chr3 | 1.40E–06 | 3.40E–09 | 4.19E–06 | 7.82E–08 | 4.19E–06 |
rs849135 | intronic | JAZF1 | chr7 | 1.45E–05 | 1.70E–09 | 3.85E–05 | 7.08E–08 | 3.85E–05 |
rs4481184 | intronic | IGF2BP2 | chr3 | 0.0002524 | 4.50E–22 | 0.0003786 | 6.55E–20 | 0.0003786 |
rs7141420 | intronic | NRXN3 | chr14 | 8.66E–15 | 0.00025 | 4.68E–13 | 0.001125 | 0.001125 |
rs6795735 | ncRNA_intronic | ADAMTS9–AS2 | chr3 | 2.92E–05 | 2.00E–04 | 0.000555 | 0.00604 | 0.00604 |
rs12895330 | intergenic | AKAP6, NPAS3 | chr14 | 9.72E–05 | 0.00021 | 0.0016041 | 0.007245 | 0.007245 |
rs2334255 | UTR3 | GIPR | chr19 | 0.0008051 | 0.00034 | 0.0114503 | 0.0176422 | 0.0176422 |
rs1783598 | intronic | FCHSD2 | chr11 | 0.0003666 | 0.00052 | 0.0064359 | 0.0193556 | 0.0193556 |
rs12245680 | intronic | TCF7L2 | chr10 | 0.01444 | 1.10E–09 | 0.02527 | 6.70E–07 | 0.02527 |
rs17584208 | intergenic | PSRC1, MYBPHL | chr1 | 4.58E–06 | 0.0016 | 0.000306 | 0.02976 | 0.02976 |
rs2488071 | intergenic | HHEX, EXOC6 | chr10 | 0.006642 | 4.70E–06 | 0.032103 | 0.0011194 | 0.032103 |
rs11979110 | intergenic | KLF14, MIR29A | chr7 | 0.00288 | 9.70E–05 | 0.03456 | 0.0140973 | 0.03456 |
rs1473 | intronic | PUM1 | chr1 | 0.0004889 | 0.00092 | 0.0114403 | 0.03542 | 0.03542 |
rs10898868 | intronic | ARAP1 | chr11 | 0.002589 | 0.00044 | 0.0370227 | 0.03608 | 0.0370227 |
rs1996023 | intergenic | GNPDA2, GABRG1 | chr4 | 1.11E–20 | 0.025 | 1.93E–17 | 0.0375 | 0.0375 |
rs825461 | intronic | ZNF664, FAM101A | chr12 | 0.0003917 | 0.0013 | 0.0114376 | 0.04472 | 0.04472 |
rs16945088 | intronic | FTO | chr16 | 5.30E–09 | 0.0072 | 1.48E–06 | 0.045 | 0.045 |
rs9540493 | intergenic | LOC10272396, LINC01052 | chr13 | 3.95E–09 | 0.0057 | 1.22E–06 | 0.0456 | 0.0456 |
rs4238585 | intergenic | GPR139, GP2 | chr16 | 1.12E–08 | 0.0069 | 3.02E–06 | 0.0483 | 0.0483 |
rs12454712 | intronic | BCL2 | chr18 | 6.04E–06 | 0.0034 | 0.0004955 | 0.0485714 | 0.0485714 |
rs4474658 | intergenic | C2CD4A, C2CD4B | chr15 | 0.009024 | 9.60E–06 | 0.0489874 | 0.0023849 | 0.0489874 |
