Table 2 Estimated effects of factors, F-ratios, and associated P-values for all responses (Y1, Y2, and Y3).

From: A PLGA-reinforced PEG in situ gel formulation for improved sustainability of hypoglycaemic activity of glimepiride in streptozotocin-induced diabetic rats

Factor

Y1

Y2

Y3

Estimate

F-ratio

P-values

Estimate

F-ratio

P-values

Estimate

F-ratio

P-values

X1

−97.77

12.14

0.0176*

−170.52

2.44

0.1788

−606.89

71.22

0.0004*

X2

−165.39

34.75

0.0020*

−108.34

32.08

0.0024*

−356.83

24.62

0.0042*

X3

−437.94

243.62

0.0001*

23.62

164.93

0.0001*

6.31

0.01

0.9335

X1 2

153.03

13.73

0.0139*

3.45

10.37

0.0235*

−217.16

4.21

0.0955

X1 X2

38.34

0.93

0.3784

1.68

2.67

0.1631

−5.61

0.00

0.9582

X1 X3

−126.77

10.21

0.0241*

−1.07

1.07

0.3475

6.67

0.00

0.9503

X2 2

33.05

0.64

0.4599

0.16

0.02

0.8848

−643.9

37.00

0.0017*

X2 X3

70.89

3.19

0.1341

2.94

8.14

0.0357*

−394.06

15.01

0.0117*

X3 2

83.22

4.06

0.1000

−1.95

3.30

0.1290

168.04

2.52

0.1733

  1. Note: *Significant effect of factors on individual dependent variables.
  2. Abbreviations: X1, PLGA %; X2, PEG %; X3, BB % in NMP; Y1, initial amount of GMD released after 2 hours (μg); Y2, amount of GMD released after 24 hours (μg); Y3, cumulative amount of GMD released after 28 days (μg); \({{\rm{X}}}_{1}^{2}\), \({{\rm{X}}}_{2}^{2}\), and \({{\rm{X}}}_{3}^{2}\) are the quadratic terms for the factors, and X1 X2, X1 X3, and X2 X3 are the interaction terms between the factors.
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