Table 1 Bactericidal activity spectrum of Csl2 and its parental enzyme Cpl-7.

From: Csl2, a novel chimeric bacteriophage lysin to fight infections caused by Streptococcus suis, an emerging zoonotic pathogen

Bacterial strain

Bactericidal activity

Csl2

Cpl-7

S. pneumoniae R6

NS

3*

S. pseudopneumoniae T

2.6 ± 0.3

3.4 ± 0.5

S. mitis T

0.4 ± 0.1

2.7 ± 0.6

S. oralis T

1.4 ± 0.2

3.3 ± 0.3

S. suis S735

4.3 ± 0.9

3.1 ± 0.3

S. mutans T

NS

0*

S. dysgalactiae sbsp. equisimilis

NS

1*

S. pyogenes T

NS

3*

S. iniae T

NS

1*

E. faecalis T

NS

2*

S. aureus T

NS

0*

  1. Killing activity of 15 µg/ml Csl2 and 5 µg/ml Cpl-7 is shown in terms of log reduction (mean ± SD). NS indicates that no significant descent in viable counts was observed with respect to the control according to one-way ANOVA. Csl2 was tested in PB pH 6.0 with 150 mM NaCl and 10 mM CaCl2, Cpl-7 in the same buffer without calcium. Cpl-7 data marked with an asterisk (*) were taken from ref.33.
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