Figure 1

TLR8 and TLR9 expressing CD14+ cells: TLR8- (upper panels) and TLR9- (lower panels) expressing CD14⁺ cells upon stimulation with specific agonists (ODN and ssRNA, respectively). Representative results in MCI individuals who did (AD-converters) or did not (AD non-converters) convert to AD over a 24-months period are presented in the left part of the figure; in the upper right corner the percentage of CD14/TLR8⁺ and CD14/TLR9⁺ cells is shown. Summary results were obtained in 21 AD converters and 25 AD non-converters and are shown in the bar graphs. The boxes stretch from the 25 to the 75 percentile; the line across the boxes indicates the median values; the lines stretching from the boxes indicate extreme values. Outside values are displayed as separate points.