Figure 2
From: Immune and Imaging Correlates of Mild Cognitive Impairment Conversion to Alzheimer’s Disease
Pro-and- anti-inflammatory cytokine mRNA expression and protein in stimulated cells: (A) Aβ1-42-stimulated IL-1β, IL-6 and IL-33 mRNA expression in MCI individuals who did (AD converters, N = 21) or did not (AD non-converters, N = 25) convert to AD over a 24-months period. Gene expression was calculated relative to GAPDH housekeeping gene. The expression of the genes is assessed by single real-time quantitative RT-PCR and shown as median of fold-change expression from the unstimulated samples. Summary results are shown in the bar graphs using TIGR Multi Experiment Viewer (MeV)v4.9. Aβ1-42-stimulated IL-1β and IL-6 production (B); IL-33 expressing CD14+ cells (%) (C), and IFN-λ production (D) in PBMC of MCI individuals who did (AD converters; N = 21) or did not (AD non-converters; N = 25) convert to AD over a 24-months period. The boxes stretch from the 25 to the 75 percentile; the line across the boxes indicates the median values; the lines stretching from the boxes indicate extreme values. Outside values are displayed as separate points. Statistical significance is shown.
