Figure 1
From: Comprehensive statistical inference of the clonal structure of cancer from multiple biopsies
Example THEMIS input observations and the corresponding inferred outputs. (a) Inputs to THEMIS, including allelic ratio, log ratio and genomic position information. Somatic mutation sites are indicated by blue diamonds. (b) Outputs of THEMIS show that there are two tumor clones in the tumor biopsy, one parent tumor clone with 40% cell prevalence and one child tumor clone with 35% cell prevalence. The CNAs of the two tumor clones are visualized with color bars across the genome, and the genomic positions hosting an SNV are indicated by blue diamonds.
