Figure 2
From: Comprehensive statistical inference of the clonal structure of cancer from multiple biopsies
Results of single cell validation experiments. (a) Predicted cell category from the Bayesian classifier: normal cell (green), parent tumor cell (red), child tumor cells (purple) and unknown due to low sequencing quality (grey). (b) Three different types of regions that we use to distinguish the three types of cells, namely clonal 2-copy regions, clonal LOH regions and subclonal LOH regions. (c) Histograms of the relative coverage rate in clonal LOH segments and subclonal LOH segments demonstrate cell 34 is normal, cell 26 is from the parent tumor clone and cell 1 is from the child tumor clone. Red dotted lines in the histograms indicate the expected coverage rates in the cells.
