Figure 3
From: Comprehensive statistical inference of the clonal structure of cancer from multiple biopsies
Experiments and results from joint analysis of three biopsies from the same patient. (a) The collection of the three biopsies from the same patient during three stages of treatment and the inferred tumor clones in the biopsies. (b) The recovered phylogenetic tree and the mutations accumulated on each edge. The mutations are shown on a genome-wide plot, and the two numbers on each edge are the number of germline heterozygous sites affected by these CNAs and the number of SNVs. (c) Signal pathways (a simplified version of signal transduction pathways from Wikipedia), and the number of genes with copy number changes (copy gain and copy loss) in different stages of cancer progression. *Denotes at least one of the mutated genes is a core component of the signaling pathway.
