Figure 2
From: BET inhibitors RVX-208 and PFI-1 reactivate HIV-1 from latency
In vitro activation of HIV-1 expression by BET inhibitors in diverse Jurkat T cell culture models. (A and C) A dose response of HIV-1 activation by BET inhibitors was determined by the quantification of GFP reporter activity after a 72-hour treatment in C11 cells (A) or A10.6 cells (C). (B and D) Time course of the induction of GFP expression by BET inhibitors. C11 cells (B) or A10.6 cells (D) were treated with 50 μM RVX-208, 5 μM PFI-1 or 1 μM JQ1 for 24 to 72 hours. Percentage of GFP-positive cells was determined by flow cytometry.
