Figure 2

Synthesis of dicarba insulins was performed via ring-closing metathesis (RCM) and an interrupted solid phase peptide synthesis (SPPS)-catalysis approach. L-Allylglycine (Agl), tert-butyl (^tBu), acetamidomethyl (Acm), S-pyridinyl (Pyr), cis isomer (Z), trans isomer (E).