Table 2 IC₅₀ (µg/ml) and SI values of all tested NPs samples against human cancer cell lines.

Free NPs

1989.8 ± 13

0.22 ± 0.004

432.5 ± 9.5

3.18 ± 0.89

925.2 ± 10.8

0.47 ± 0.007

736.9 ± 19.6

1.87 ± 0.061

LPO

2029.4 ± 25

0.41 ± 0.009

873.9 ± 7.4

0.95 ± 0.03

1926.9 ± 17

0.43 ± 0.018

1154.3 ± 12

0.72 ± 0.02

LPO-loaded NPs

813.1 ± 60.3

3.15 ± 0.01

503.2 ± 20.2

5.1 ± 0.02

339.7 ± 4.5

7.5 ± 1.6

776.8 ± 7.9

3.29 ± 0.015

LPO coated NPs

1496.3 ± 11

0.55 ± 0.01

703.8 ± 52

1.72 ± 0.12

374.7 ± 7.8

2.4 ± 0.03

847.2 ± 14.2

1.43 ± 0.1

LF

2282.2 ± 21

0.36 ± 0.006

636.2 ± 21

1.28 ± 0.02

1955.6 ± 37

0.42 ± 0.003

874.7 ± 6.3

0.93 ± 0.01

LF-loaded NPs

1285.2 ± 59

1.06 ± 0.04

510.6 ± 15

2.66 ± 0.98

269.7 ± 6.2

5.03 ± 0.19

812.2 ± 4.5

1.67 ± 0.06

LF coated NPs

755.1 ± 84

3.06 ± 0.11

463 ± 29

5.0 ± 0.18

189.1 ± 7.2

12.26 ± 0.44

605.2 ± 21.4

3.82 ± 0.14

LPO + LF

1980.9 ± 13

0.45 ± 0.008

545.6 ± 18

1.65 ± 0.02

1846.6 ± 7.7

0.49 ± 0.008

730.1 ± 4.4

1.23 ± 0.016

LPO + LF-loaded NPs

816.6 ± 42

4.02 ± 0.42

472.8 ± 15

6.94 ± 0.07

215.9 ± 3

15.21 ± 0.16

620.3 ± 17

5.3 ± 0.057

LPO + LF coated NPs

1173.9 ± 70

0.94 ± 0.05

540.5 ± 8

2.04 ± 0.1

713.6 ± 15.5

1.54 ± 0.081

811.8 ± 38

1.38 ± 0.07

LF coated LPO-loaded NPs

669.2 ± 40

3.16 ± 0.02

256.9 ± 38

8.23 ± 0.05

150.1 ± 4.8

14.1 ± 0.093

539.3 ± 29

3.92 ± 0.026

LPO coated LF-loaded NPs

968.4 ± 77

1.04 ± 0.11

542.7 ± 29

1.8 ± 0.02

244.7 ± 14

4.1 ± 0.26

815.5 ± 42

1.23 ± 0.07

5-FU

1.09 ± 0.02

1.74 ± 0.1

1.23 ± 0.05

1.53 ± 0.05

1.60 ± 0.05

1.19 ± 0.12

1.46 ± 0.04

0.72 ± 0.02