Figure 4
From: Anti-IL-20 monoclonal antibody inhibited tumor growth in hepatocellular carcinoma
Tumor growth in vivo was significantly lower in 7E-treated mice. ML-1 cells were injected into the fat pads of BALB/c mice. One day later, the mice were injected s.c. with PBS (n = 4), 7E (6 mg/kg) and mIgG (6 mg/kg) (n = 5 in each group) twice per week for 25 d. (A) Tumor size was measured using a vernier caliper. Values are means ± SD. Data are representative of three independent experiments. (B) Mice were killed 25 days after they had been treated with antibody, and their tumors were collected and weighed. Values are means ± SD. Data are representative of three independent experiments. (C–F) Cyclin D1, TNF-α, VEGF and MMP-9 mRNA expression in tumor tissue was analyzed using qRT-PCR with specific primers. *P < 0.05 versus mIgG controls. Values are means ± SD. Data are representative of three independent experiments.
