Figure 4
From: Cell-Free DNA Kinetics in a Pre-Clinical Model of Head and Neck Cancer
Plasma ctDNA and total plasma DNA correlation with tumour and lymph node volume. (a) Summary of tumour volume (blue), lymph node volume (red), plasma ctDNA concentration (green closed), and total DNA concentration (green open) for all rabbits in the study (n = 9). Vertical dotted line (black) represents the day of tumour resection surgery for Rabbits 6, 7, and 8. Asterisks at specific time points indicate a value of 0 corresponding to the color of the data point (i.e. blue asterisk at day 3 = tumour volume is 0 mm3). Error bars represent SD. n.d. denotes not detectable. (b) Scatter plots showing correlation between ctDNA and tumour volume (filled circles, ii) and between total plasma DNA and tumour volume (open circles, i) at all pre-operative time points for all rabbits in the study (n = 9 rabbits; n = 48 total individual timepoints). Linear regression trend lines are shown. (c) Correlation (Pearson r, mean ± 95% confidence interval) between plasma ctDNA or total plasma DNA and the indicated volume parameter for pre-operative timepoints for all rabbits. Asterisks indicate P < 0.05.
