Figure 5
From: Cell-Free DNA Kinetics in a Pre-Clinical Model of Head and Neck Cancer
Effect of necrosis on plasma ctDNA levels. (a) Correlation (Pearson r, mean ± 95% confidence interval) between plasma ctDNA and the indicated volume parameter for pre-operative timepoints in which tumour was visible by CT in all rabbits (n = 8 rabbits; n = 29 total individual timepoints). (b) Representative CT images demonstrating Rabbit 4 primary VX2 tumour growth. Yellow boxes highlight region of tumour growth. (c) Relationship between plasma ctDNA and total tumour volume (i), necrotic tumour volume (ii) and viable/solid tumour volume (iii) for Rabbit 4. Blue asterisks denote non-detectable tumour size. Error bars for ctDNA values represent SD.
