Figure 2
From: Deep mutational scanning of S. pyogenes Cas9 reveals important functional domains
Predicted SpCas9 library composition. (a) Red bars represent predicted number of transformants with the indicated number of amino acid mutations. Blue bars represent the number of transformants with the indicated number of DNA mutations. (b) Counts of the number of accessed amino acid mutations. Colors indicate the number of each mutation found in the indicated domain. (c) Plot of the number of nonsynonymous mutations accessed at each position in SpCas9.
