Table 1 Genome-wide significant loci identified in a GWAS meta-analysis of n = 15,997 participants of Hispanic/Latino ancestry from four studies, that were previously reported.

From: GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals

Locus

Lead SNP

Chr

Position (hg19)

A1

A2

CAF

β (ms)

Direction of β

SE (ms)

P-val

Phet

RNF207

rs7531322

1

6,299,823

C

G

0.30

1.73

++++

0.24

1.04e–12

0.17

NOS1AP

rs12143842

1

162,033,890

T

C

0.22

3.46

++++

0.25

3.30e–42

0.35

ATP1B1

rs12035622

1

169,102,340

A

T

0.19

−2.36

−−−−

0.27

8.77e–18

0.73

SLC8A1

rs35450971

2

40,754,314

T

C

0.79

1.71

++++

0.26

8.37e–11

0.45

TTN

rs55863869

2

179,647,546

A

G

0.84

−1.92

−−−−

0.30

2.40e–10

0.42

SCN5A

rs3922844

3

38,624,253

T

C

0.37

1.77

++++

0.22

9.52e–16

0.06

SLC35F1

rs2078383

6

118,706,643

T

C

0.25

1.83

++++

0.25

2.07e–13

0.82

KCNH2

rs35760656

7

150,658,678

A

G

0.35

1.70

++++

0.23

4.21e–13

0.50

KCNQ1

rs12271931

11

2,478,519

A

G

0.93

3.92

??++

0.57

4.07e–12

0.13

LITAF

rs735951

16

11,693,536

A

G

0.41

−1.55

−−−−

0.22

5.92e–13

0.78

SETD6

rs185639574

16

58,550,052

T

G

0.34

−2.53

−−−−

0.24

6.67e–27

0.52

PRKCA

rs56152251

17

64,280,153

A

G

0.44

−1.60

−−−−

0.21

6.64e–14

0.85

KCNE1

rs12626657

21

35,828,173

A

G

0.15

2.69

+++−

0.31

1.14e–17

0.01

  1. Chr: chromosome number. Position: base pair position in Build 37 (hg19). A1, A2: coded/non-coded alleles. β: effect estimate in ms. Direction of β: direction of the effect estimates per study following this order: WHI, MESA, HCHS/SOL and Starr County; ‘?’ means the SNP is not present in that particular study. SE: standard error. Phet: P-val for Cochran’s Q test of homogeneity among cohorts.
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