Table 2 Genome-wide significant secondary SNPs from previously reported regions, identified in meta-analyzed conditional analysis.

From: GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals

Locus

SNP

Chr

Position (hg19)

A1

A2

CAF

β (ms)

Direction of β

SE (ms)

P-val

PHet

NOS1AP

rs3934467

1

162,182,677

T

C

0.28

1.62

++++

0.24

2.26e–11

0.78

 

rs73017364

1

162,184,746

T

C

0.87

1.73

++++

0.31

3.74e–08

0.65

ATP1B1

rs1320977

1

169,073,388

A

G

0.15

−2.30

−−−+

0.29

2.61e–15

0.02

 

rs1138486

1

169,101,935

T

C

0.14

−2.46

−−−?

0.31

6.98e–15

0.55

SCN5A

rs6762565

3

38,582,191

T

C

0.19

−1.65

?−−?

0.29

1.94e–08

0.19

KCNQ1

rs78695585

11

2,644,544

A

G

0.04

3.48

++++

0.59

2.82e–09

0.63

  1. Chr: chromosome number. Position: the base pair position in Build 37 (hg19). A1, A2: coded/non-coded alleles. CAF: coded allele frequency. β: effect estimate in ms for the highest associated SNP upon conditional analysis. Direction: the direction of the effect estimates; order is WHI, MESA, HCHS/SOL, and Starr County; ‘?’ means the SNP was not present for a particular study. SE: standard error (ms). Phet: P-val for Cochran’s Q test of homogeneity among cohorts, for the highest associated SNP upon conditional analysis.
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