Figure 2
(A) Representative 18F-FDG PET images of ZL control (left), diabetic ZDF rat on a no-restriction diet (ZDF-ND, middle) and diabetic ZDF rat after three weeks of mild calorie restriction (ZDF-CR, right). Intense focal 18F-FDG uptake of BAT in the interscapular area was clearly depicted in the ZL control rat, while no apparent uptake was observed in the ZDF-ND rat (arrows). After calorie restriction (ZDF-CR), mild tracer uptake was identified in the interscapular area indicating improved BAT glucose utilization. (B) Average time-activity curves of BAT in ZL control rats, with calorie restriction (ZDF-CR), and ZDF rats with no-restriction diet (ZDF-ND) (upper). Bar graph of FDG uptake (%ID) of BAT in ZL control, ZDF-ND, and ZDF-CR rats at the time point of 30 min after 18F-FDG injection (lower). BAT = brown adipose tissue. *p < 0.01, **p < 0.001 and ***p < 0.0001.
