Figure 3
From: Altered spontaneous calcium signaling of in situ chondrocytes in human osteoarthritic cartilage
Characterization of spatiotemporal features of spontaneous [Ca2+]i signaling in chondrocyte of health (ICSR 0) and early OA samples (ICRS 1). Representative [Ca2+]i oscillation curves of chondrocytes located in superficial, middle, and deep zones of (a) ICRS 0 and (c) ICRS 1 sample, spatiotemporal features (calcium peak magnitude, number of peaks, and responsive rate) of spontaneous [Ca2+]i signaling in chondrocyte located in different zones of (b) ICRS 0 and (d) ICRS 1 samples when cultured in either 0 mM or 4 mM [Ca2+]e environments. Results were expressed as mean ± SEM (for calcium peak magnitude and number of peaks, 15–102 cells were analyzed; for responsive rate, 4 individual samples were analyzed in superficial zones, and 10–20 chondrons were analyzed in middle and deep zones, * P < 0.05; ** P < 0.01).
