Figure 2

Boxplots of metabolite concentrations in plasma samples from newborns included in the HYPOTOP trial. Note: acetoacetate, succinate, malate and α-ketoglutarate detected in 77, 95, 92 and 60% and other analytes in 100% of samples, concentrations < LLOQ were set to 1/2xLLOQ; p-values calculated employing the two-tailed Wilcoxon rank sum test for equal medians.