Table 4 Main descriptors of the distribution of concentrations (µmol L−1) in plasma samples collected from the control group (N = 19) and newborns enrolled in the HYPOTOP trial 48 h after the administration of the first dose of TPM. Note: p-value calculated employing the two-tailed Wilcoxon rank sum test for equal medians (α = 0.05).
Metabolite | Control Group | HYPOTOP (48 h) | p-value | ||||||
|---|---|---|---|---|---|---|---|---|---|
Range P10-P90 | Median | Mean ± s | >LLOQ (%) | Range P10-P90 | Median | Mean ± s | >LLOQ (%) | ||
Pyruvate | 6–50 | 11 | 100 ± 200 | 100 | 12–200 | 40 | 100 ± 200 | 100 | 1.6 × 10−5 |
Lactate | 300–1000 | 700 | 700 ± 400 | 100 | 500–3000 | 1000 | 1600 ± 2000 | 100 | 0.002 |
Acetoacetate | 20–700 | 100 | 300 ± 300 | 100 | 0.7–30 | 7 | 35 ± 130 | 82 | 1.7 × 10−8 |
β-Hydroxybutyrate | 13–700 | 150 | 300 ± 300 | 100 | 4–15 | 8 | 9 ± 5 | 100 | 4.9 × 10−8 |
Succinate | 0.13–0.7 | 0.3 | 0.4 ± 0.3 | 95 | 0.11–0.8 | 0.5 | 0.4 ± 0.2 | 100 | 0.235 |
Fumarate | 0.5–1.1 | 0.7 | 0.7 ± 0.2 | 79 | 0.3–1.3 | 0.6 | 0.8 ± 0.8 | 100 | 0.234 |
Malate | 1.0–8 | 1.2 | 3 ± 4 | 100 | 0.7–5 | 2 | 3 ± 4 | 92 | 0.535 |
α-Ketoglutarate | 0.5–2 | 1.2 | 1.3 ± 0.6 | 74 | 0.02–7 | 1.2 | 2 ± 4 | 81 | 0.672 |
