Figure 3

Subtype-specific functional groups of prognostic genes. (a) Luminal (ER-positive/PR-positive) specific prognostic genes and functional groups. In total, 83.7% and 16.3% of prognostic genes (n = 557) were adverse and favorable, respectively; 54.6% and 11.5% of the adverse and favorable prognostic genes, respectively, were assigned to functional groups through Reactome pathway enrichment analysis (upper panel). (b) Triple-negative (ER-negative/PR-negative/HER2-negative)-specific prognostic genes and functional groups: 65.2% and 34.8% of the prognostic genes (n = 557) were adverse and favorable, respectively. In total, 44.2% and 24.4% of the adverse and favorable prognostic genes, respectively, were assigned to Reactome functional groups (upper panel). Representative functional groups of adverse (red) and favorable (blue) prognostic genes (lower panel). The colors of the bars in the figure indicate the outcome relation (adverse or favorable), and the enriched and non-enriched portions of the prognostic genes. X-axis: common logarithm of the false discovery rate (FDR).