Table 1 Antibacterial activity of γ-ACT and comparator agents against S. aureus SH1000 and derivatives lacking enzymes important in the detoxification of ROS.

From: Revisiting unexploited antibiotics in search of new antibacterial drug candidates: the case of γ-actinorhodin

 

Minimum inhibitory concentration (µg/ml)

γ-ACT

DAP

CTAB

VAN

CIP

RIF

SH1000

1

1

1

1

0.25

0.016

KS100

1

1

1

1

0.12

0.016

KC043

1

1

1

1

0.25

0.016

MHKA

0.12

1

1

1

0.12

0.016

MHKM

1

1

1

1

0.12

0.016

MHKAM

0.06

0.5

1

1

0.12

0.008

  1. γ-ACT: γ-actinorhodin, DAP: daptomycin, CTAB: cetyltrimethylammonium bromide, VAN: vancomycin, CIP: ciprofloxacin, RIF: rifampicin.