Figure 5 | Scientific Reports

Figure 5

From: Peretinoin, an acyclic retinoid, inhibits hepatocarcinogenesis by suppressing sphingosine kinase 1 expression in vitro and in vivo

Figure 5

Effects of SPHK1 knockout on hepatocarcinogenesis in a DEN-induced hepatoma mouse model. DEN was injected into the peritoneal cavity of 2-week-old SPHK1 knockout, SPHK1 Tg, and wild-type mice at 25 mg/kg, and then those mice were sacrificed at 40 weeks old. (a) The numbers of mice that had a liver tumor at sacrifice. (b) The numbers of liver tumors in each mouse. (c) The maximum liver tumor size in individual mice that developed hepatoma. (d) Macrophotographs of representative mouse livers at sacrifice. (e) High power field microphotographs of representative mouse liver tumors stained with hematoxylin and eosin. Error bars shows the standard deviation from at least 20 mice, and the statistical significance of the difference in the average between these two groups was analyzed by the Student’s t test. *p < 0.05, ***p < 0.005

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