Table 2 Summary of histological observations according to the initial doses of infection, the infected explant and the day of culture.

From: Three-dimensional (3D) culture of adult murine colon as an in vitro model of cryptosporidiosis: Proof of concept

Explant identification (D = day Post-Infection)

Infective dose of C. parvum

Epithelium conservation

Presence of parasites according to microscopic observation

Presence of neoplasia

25(1)-D10

25 oocysts

Yes

No

No

25(2)-D10

Yes

No

No

25(3)-D10

No

N/A

N/A

25(1)-D12

Yes

No

No

25(2)-D12

No

N/A

N/A

25(3)-D12

Yes

No

No

25(1)-D14

Yes

No

No

25(2)-D14

No

N/A

N/A

25(3)-D14

Yes

Yes

No

25(1)-D21

No

N/A

No

25(2)-D21

Yes

Yes

No

25(3)-D21

Yes

Yes

No

25(1)-D30

Yes

Yes

No

25(2)-D30

Yes

Yes

No

25(3)-D30

No

N/A

N/A

25(1)-D32

Yes

Yes

No

25(2)-D32

Yes

Yes

No

25(3)-D32

No

N/A

N/A

25(1)-D35

No

N/A

N/A

25(2)-D35

Yes

Yes

Yes

25(3)-D35

Yes

Yes

Yes

250(1)-D10

250 oocysts

Yes

Yes

No

250(2)-D10

Yes

Yes

No

250(3)-D10

Yes

Yes

No

250(1)-D12

No

N/A

N/A

250(2)-D12

No

N/A

N/A

250(3)-D12

Yes

Yes

No

250(1)-D14

Yes

Yes

No

250(2)-D14

Yes

Yes

No

250(3)-D14

Yes

Yes

No

250(1)-D21

No

N/A

No

250(2)-D21

Yes

Yes

No

250(3)-D21

Yes

Yes

No

250(1)-D30

Yes

Yes

No

250(2)-D30

No

N/A

N/A

250(3)-D30

Yes

Yes

N/A

  1. N/A: not applicable.