Figure 3
From: Lactation has persistent effects on a mother’s metabolism and mitochondrial function
Respiration and oxidant emission from isolated mitochondria for age-matched rats that did not reproduce (NR), and rats that did not (NL) or did (L) suckle their young. Data include liver (A) state 3 respiration utilizing complex I substrates (pyruvate and malate; P/M), (B) state 4 respiration utilizing P/M, (C) respiratory control ratio (RCR) utilizing P/M), (D) state 3 respiration utilizing complex II substrates (succinate; suc), (E) state 4 respiration utilizing Suc, (F) RCR utilizing suc. Data also include skeletal muscle (G) state 3 respiration utilizing P/M, (H) state 4 respiration utilizing P/M, (I) RCR utilizing P/M, (J) state 3 respiration utilizing suc, (K) state 4 respiration utilizing suc, (L) RCR utilizing suc. Finally (M) oxidant emission from liver and (N) oxidant emission from skeletal muscle are also presented. Oxygen consumption and hydrogen peroxide (H2O2) rates are normalized to citrate synthase (CS). Data shown are mean ± SD (n = 6–8 per group). *Different from NR, and # different from NL (p < 0.05).
