Figure 1

MR imaging before and 24 hours after treatment. Representative baseline ADC and CBF maps (upper row) from a control group (right column) and a treatment group (left column) before treatment, showing no significant differences of the lesion volumes within the right MCA territory. Representative ADC and T2 24 hours after stroke induction (lower row) of a treated mouse (left column) and a control mouse (right column), showing smaller ADC and T2 lesions 24 hours after treatment with tacrolimus compared to the lesions of the NaCl-treated control.