Table 3 Proteins identified by LC-MS/MS with the most significant changes in their expression levels in dry eye (DE), Meibomian gland dysfunction (MGD), and control (CT) groups.

P01024

Complement C3

C3

5.66E-05

1.86

DE

CT

6

P06703

Protein S100-A6

S100A6

5.40E-08

2.26

DE

CT

2

P05109

Protein S100-A8

S100A8

1.68E-04

2.15

DE

CT

4

P00450

Ceruloplasmin

CP

3.76E-02

3.25

DE

CT

2

P05090

Apolipoprotein D

APOD

8.68E-03

3.85

DE

CT

3

P19652

Alpha-1-acid glycoprotein 2

ORM2

1.69E-04

2.13

DE

CT

4

P10599

Thioredoxin

TXN

4.14E-04

1.61

DE

MGD

3

P01857

Ig gamma-1 chain C region

IGHG1

4.14E-04

1.61

DE

MGD

10

P14555

Phospholipase A2, membrane-associated

PLA2G2A

1.77E-02

3.13

DE

MGD

7

P01009

Alpha-1-antitrypsin

SERPINA1

4.05E-03

1.98

DE

MGD

5

P03973

Antileukoproteinase

SLPI

2.32E-02

3.59

DE

MGD

3

P04083

ANXA1 protein

ANXA1

1.46E-03

1.83

MGD

CT

2

P10909

Clusterin

CLU

1.52E-02

2.68

MGD

CT

8

P02763

Alpha-1-acid glycoprotein 1

ORM1

1.75E-02

1.49

MGD

CT

4

P22079

Lactoperoxidase

LPO

1.73E-02

2.40

MGD

DE

2

Q99935

Proline-rich protein 1

PROL1

5.82E-03

1.64

CT

DE

8

O95968

Secretoglobin family 1D member 1

SCGB1D1

2.00E-02

1.63

CT

DE

5

O75556

Mammaglobin-B

SCGB2A1

3.56E-03

1.65

CT

DE

11

P31025

Lipocalin-1

LCN1

3.61E-02

1.81

CT

DE

11

P01036

Cystatin-S

CST4

3.56E-03

1.65

CT

DE

6

P12273

Prolactin-inducible protein

PIP

3.69E-02

1.9

CT

DE

8

P81605

Dermcidin

DCD

6.27E-03

2.55

CT

DE

2

P02814

Submaxillary gland androgen-regulated protein

PROL3

3.44E-02

1.61

CT

DE

4

Q08380

Galectin-3-binding protein

LGALS3BP

4.61E-02

2.64

CT

DE

2

Q9GZZ8

Extracellular glycoprotein lacritin

LACRT

2.19E-02

1.83

CT

DE

6

Q16378

Proline-rich protein 4

PRR4

3.23E-02

2.02

CT

DE

4