Table 4 Involvement of each module in different biological processes, showing the proteins implicated in each process⁴².

1

inflammatory response

6

<1.000E-03

IL6, TNF, S100A8, RELA, S100A9, S100A12

positive regulation of chemokine production

3

<3.333E-04

IL6, TNF, TLR4

response to lipopolysaccharide

4

2.50E-04

IL6, S100A8, S100A9, TLR4

cytokine-mediated signaling pathway

3

1.06E-03

IL6, RELA, STAT3

extrinsic apoptotic signaling pathway

2

9.44E-04

TNF, TRADD

acute-phase response

2

4.03E-03

IL6, STAT3

cell redox homeostasis

2

4.26E-03

IL6, TXN

innate and humoral immune response

4

5.80E-03

RELA, TXN, TLR4, S100A12

positive regulation of JNK cascade

2

4.20E-02

TNF, TLR4

cellular defense response

2

4.73E-02

LGALS3BP, RELA

2

extracellular matrix organization

5

<5.000E-04

MMP9, TIMP2, MMP2, MMP1, TIMP1

collagen catabolic process

3

3.33E-04

MMP9, MMP2, MMP1

response to cytokine stimulus

3

3.00E-03

JUN, SERPINE1, TIMP1

angiogenesis

4

2.67E-03

IL8, JUN, MMP2, ANXA2

aging

3

1.26E-02

JUN, IL1B, TIMP1

response to hypoxia

2

1.30E-02

MMP9, SERPINE1

negative regulation of cell proliferation

4

1.22E-02

IL8, JUN, IL1B, TIMP2

neutrophil chemotaxis

2

1.63E-02

IL8, IL1B

cellular response to interleukin-1

2

1.49E-02

IL8, MMP9

response to hypoxia

3

1.72E-02

MMP9, IL1B, MMP2

3

defense response to bacterium

4

3.52E-03

PLA2G2A, CST4, LCN1, LTF

positive regulation of inflammatory response

5

4.73E-03

C3, APOD, ORM1, ORM2, PLA2GSA

4

signal transduction

4

1.90E-03

S100A6, S100A11, ANXA1, S100A10

apoptosis

4

1.82E-03

S100A6, S100A11, ANXA1, S100A10

fibroblast proliferation

4

3.74E-03

S100A6, S100A11, ANXA1, S100A10