Table 3 Predictors of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia: simple log-binomial regression univariate analyses.

From: Cardiometabolic Risk Factors in Childhood, Adolescent and Young Adult Survivors of Acute Lymphoblastic Leukemia – A Petale Cohort

 

Obesity

Dyslipidemia

Prediabetes

Pre-AHT/AHT

Metabolic syndrome (NCEP)

Metabolic syndrome (IDF)

≥2 Risk factors

Relative Risk (95% CI)

CRT (yes vs. none)

1.36 (0.93–2.00)

1.56* (1.11–2.18)

4.76 (0.60–38.11)

1.87 (0.87–4.03)

2.60 (0.60–11.19)

2.33 (0.89–6.11)

1.76* (1.07–2.90)

Gender (males vs. females)

0.60 (0.41–0.88)

1.02 (0.76–1.38)

0.34 (0.07–1.66)

4.10* (1.74–9.68)

0.57 (0.20–1.62)

1.24 (0.56–2.76)

0.87 (0.56–1.35)

Age at diagnosis (per unit of year)

1.02 (0.98–1.06)

1.02 (0.99–1.05)

1.09 (0.96–1.24)

1.02 (0.95–1.09)

1.01 (0.92–1.12)

1.06 (0.98–1.14)

1.02 (0.98–1.07)

Age at interview (per unit of year)

1.03* (1.00–1.06)

1.04* (1.02–1.06)

1.11* (1.01–1.22)

1.01 (0.96–1.06)

1.03 (0.94–1.13)

1.09* (1.03–1.15)

1.06* (1.02–1.09)

Obesity at the end of treatment (yes vs. none)

2.17* (1.47–3.21)

1.09 (0.72–1.65)

1.01 (0.12–8.82)

1.07 (0.42–2.68)

2.33 (0.74–7.35)

3.23* (1.28–8.14)

1.70 (0.98–2.94)

Δ Percentile BMI (unit = 5%)

1.03 (0.98–1.07)

0.98 (0.94–1.01)

1.03 (0.87–1.22)

0.99 (0.91–1.07)

1.06 (0.96–1.18)

1.06 (0.96–1.16)

1.02 (0.97–1.08)

  1. Simple log-binomial regression analysis for each cardiometabolic complication as a function of each predictor was performed. CRT: cranial radiotherapy; BMI: body mass index; AHT: arterial hypertension; IDF: International diabetes Federation; NCEP, National Cholesterol Education Program - Adult Treatment Panel III (NCEP-ATP III); CI: confidence interval. Δ BMI percentile = percentile BMI at end of treatment - percentile BMI at diagnosis. *P < 0.05.
Back to article page