Table 2 The core PharmaADME genes containing SNPs with minor allele frequencies greater than 1% in the southern Han-Chinese population.

From: Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population

Phase I enzymes

Phase II enzymes

Transporters and Other Genes

Gene

SNP count

Gene

SNP count

Gene

SNP count

CYP2C9

2

SULT1A1

1

SLC22A2

1

CYP2C8

1

UGT2B15

1

SLCO1B3

2

CYP2B6

2

UGT1A1

3

SLCO2B1

1

CYP2D6

3

UGT2B7

1

SLC15A2

4

CYP3A4

1

DPYD

4

SLC22A1

3

CYP3A5

2

GSTM1

1

SLCO1B1

2

CYP1A1

1

GSTP1

1

ABCB1

6

CYP1A2

3

NAT1

5

ABCC2

6

CYP2A6

3

NAT2

6

ABCG2

2

CYP2C19

2

TPMT

1

VKORC1*

1

  1. *VKORC1 is the therapeutic target of warfarin and is associated with sensitivity to the drug.
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