Table 1 72-hour culture test from panel of methicillin sensitive and resistant S. aureus clinical isolate biofilms after 24 hours of treatment with cefazolin or WLBU2 at 10x MIC. Each strain repeated at least three separate times in triplicate.

From: Elimination of Antibiotic Resistant Surgical Implant Biofilms Using an Engineered Cationic Amphipathic Peptide WLBU2

Clinical Isolate

Cefazolin Treated

Vancomycin Treated

WLBU2 Treated

MSSA-1

100% (12/12)

100% (10/10)

0% (0/10)

MSSA-2

100% (9/9)

100% (9/9)

0% (0/9)

MSSA-3

100% (9/9)

100% (9/9)

0% (0/9)

MSSA-4

100% (9/9)

25% (3/12)

0% (0/9)

MRSA-1

100% (9/9)

100% (9/9)

0% (0/9)

MRSA-2

100% (9/9)

100% (9/9)

0% (0/9)

MRSA-3

100% (9/9)

50% (5/10)

0% (0/9)

MRSA-4

100% (9/9)

100% (9/9)

0% (0/9)

MRSA-5

100% (9/9)

100% (9/9)

0% (0/9)