Table 1 Gene ontology (GO) terms for changes in motor neuron mRNA expression after miR-124 overexpression.

From: High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria

Gene Ontology term

genes count

P-value

Organelle envelope

27

1.80E-05

Envelope

27

1.90E-05

Mitochondrial part

24

2.30E-04

Organelle inner membrane

23

1.80E-07

Mitochondrial membrane

22

1.00E-05

Mitochondrial envelope

22

2.50E-05

Mitochondrial inner membrane

21

1.30E-06

Inorganic cation transmembrane transporter activity

16

8.40E-09

Monovalent inorganic cation transmembrane transporter activity

14

4.70E-09

Hydrogen ion transmembrane transporter activity

13

2.40E-08

Redox-active center

8

4.60E-06

Cell redox homeostasis

8

1.00E-04

Thioredoxin-like

6

3.40E-04

Thioredoxin-like

6

3.40E-04

Disulphide isomerase

5

1.20E-06

Domain:Thioredoxin 2

5

9.30E-06

Domain:Thioredoxin 1

5

9.30E-06

Thioredoxin-like subdomain

5

2.50E-05

Thioredoxin, conserved site

5

7.80E-04

Thioredoxin domain

5

9.10E-04

Oxidoreductase activity, acting on heme group of donors, oxygen as acceptor

5

6.90E-04

Oxidoreductase activity, acting on heme group of donors

5

6.90E-04

Cytochrome-c oxidase activity

5

6.90E-04

Heme-copper terminal oxidase activity

5

6.90E-04

PIRSF001487:protein disulfide-isomerase

4

1.90E-04

Protein disulfide isomerase activity

4

3.00E-04

Intramolecular oxidoreductase activity, transposing S-S bonds

4

3.00E-04

Intramolecular oxidoreductase activity, interconverting keto- and enol-groups

4

4.50E-04

Intramolecular oxidoreductase activity

4

3.10E-02

Protein disulphide isomerase

3

1.70E-03

  1. Top 30 Gene ontology (GO) term analysis of up- or downregulated mRNAs after miR-124 overexpression (corrected P-value < 0.05). Table columns include DAVID46 term names, number of genes counted in each category and p-value for the statistical significance of the category. There is noticeable overrepresentation of gene ontology terms related to mitochondria structure or function in response to miR-124.