Figure 2
From: Heritability of the melatonin synthesis variability in autism spectrum disorders
Narrow sense heritability estimates (h2) of the biochemical traits associated with the melatonin synthesis pathway. Heritability was calculated using the variance component analysis with maximum likelihood estimation method. When the effect of the covariates (age, sex) was significant (P < 0.1), they were included in the model. The significance of heritability estimates is assessed using a loglikelihood ratio test that compares the polygenic model to a sporadic model in which the additive genetic effect is constrained to zero. n, number of participants; dots, h2 estimates; error bars, standard errors. *Bonferroni corrected P-value < 0.05 (15 tests were performed, p-values < 3.3 × 10−3 (0.05/15) were considered as significant).
