Figure 3
From: Heritability of the melatonin synthesis variability in autism spectrum disorders
Heritability analysis of the melatonin synthesis pathway in families with ASD. (a) Bivariate heritability analyses. Pairwise phenotypic correlations (ρP), additive genetic correlations (ρG) and shared environmental correlations (ρE). Correlations calculated in patients with ASD are on the upper diagonal; correlations calculated in unaffected siblings are on the lower diagonal. P-values test the significance of the difference of ρP, ρG and ρE from zero. The diamond shape used for the phenotypic correlation between ASMT and NAS in unaffected individuals means that the p-value could not be tested according to SOLAR. *Significant p-values after Bonferroni correction: 60 tests were performed, p-values < 8.33 × 10−4 (0.05/60) were considered as significant. (b) Overview of heritability analyses results for the biochemical traits associated with the melatonin synthesis pathway in patients with ASD and in unaffected individuals. Circle sizes represent heritability estimates. Circle colors represent the proportion of patients or unaffected siblings with biochemical values >95th percentile of controls in purple and <5th percentile of controls in green, as previously published13,19. Grey curved lines represent environmental and genetic correlations with nominal P-values < 0.05 and their thickness is proportional to correlation values. *Significant correlations after Bonferroni correction.
