Table 1 Tested sham combinations of Cokol et al.8 at 8 hours and 12 hours.

From: BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism

Time

ANI

BRO

C3P

CAN

CYC

HAL

MET

MMS

MYR

QMY

RAP

STA

TAM

TUN

08h00

0

1

0

0

0

0

1

0

0*

0

0

0

1

0

12h00

0

0

0

0

0

0

1

0

0

0

0

0

0

0

  1. 0 indicates additive call, 1 indicates antagonism and -1 indicates synergy. 4 sham combinations are found to be antagonistic. *For Myr-Myr combination the p value of MeanR was borderline significant (p = 0.047), but no significant calls for MaxR.
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