Table 1 MICs and MBCs of sphingosine, short-chain C6-ceramide, long-chain C16-ceramide and C6/C16-ceramide analogs against N. meningitidis, N. gonorrhoeae, E. coli and S. aureus.
From: Antibacterial activity of ceramide and ceramide analogs against pathogenic Neisseria
Compound | N. meningitidis (MC58) | N. gonorrhoeae (FA1090) | ||||
|---|---|---|---|---|---|---|
a*MIC | **MIC>50 | #MBC | *MIC | **MIC>50 | #MBC | |
sphingosine | 4 | 1.97 | 4 | 4 | 1.25 | 8 |
C6-ceramide | 2 | 0.69 | 64 | 1 | 0.18 | >64 |
α-C6-ceramide | >64 | — | >64 | >64 | — | >64 |
ω-C6-ceramide | 2 | 0.8 | 4 | 2 | 0.8 | 4 |
C16-ceramide | 16 | 8.39 | >64 | >64 | — | >64 |
α-C16-ceramide | 64 | 16.4 | 64 | 32 | 21 | 64 |
ω-C16-ceramide | >64 | — | >64 | >64 | — | >64 |
Compound | E. coli ATCC 25922 | S. aureus ATCC 29213 | ||||
a* MIC | ** MIC >50 | # MBC | * MIC | ** MIC >50 | # MBC | |
sphingosine | 16 | 8.39 | 16 | 8 | 1.22 | >64 |
C6-ceramide | >64 | — | >64 | >64 | — | >64 |
α-C6-ceramide | >64 | — | >64 | >64 | — | >64 |
ω-C6-ceramide | >64 | — | >64 | >64 | — | >64 |
C16-ceramide | >64 | — | >64 | >64 | — | >64 |
α-C16-ceramide | >64 | — | >64 | >64 | — | >64 |
ω-C16-ceramide | >64 | — | >64 | >64 | — | >64 |
