Figure 1 | Scientific Reports

Figure 1

From: Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells

Figure 1

Intracellular TFV-DP concentrations from TFV/TAF treatment in CD4+ T cells from blood and female reproductive tract tissues. TFV-DP concentrations were measured by LC-MS/MS in purified CD4+ T cells from blood (n = 11) and from FRT (Endometrium: n = 17, Cervix: n = 5, Ectocervix: n = 5) treated with TFV (3277 µM) or TAF (2 µM) for 24hr. Values are expressed as fmol/million cells. Each symbol represents blood CD4+ T cells from different female donors or FRT CD4+ T cells from an individual patient. Dark squares indicate blood CD4+ T cells. Dark circles indicate endometrial CD4+ T cells. Open circles indicate cervix CD4+ T cells and triangles indicate ectocervix CD4+ T cells. The mean and SEM are shown.

Back to article page