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Figure 2

From: Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells

Figure 2

Dose response and comparison of TFV and TAF inhibition of HIV infection of CD4+ T cells from blood and endometrium (EM). Activated CD4+ T cells from blood and endometrium were pre-treated with TFV or TAF for 24hr and inoculated with HIV for 2hr. Released p24 levels in the culture media after 5 days of infection were measured by p24 enzyme-linked immunosorbent assay. Released p24 levels into the culture media after 5 days of infection when blood CD4+ T cells from same female donor were pre-treated with indicated doses of TFV (a) or TAF (b). The bar represents the mean and SEM from triplicate cultures. Effect of increasing concentrations of TFV (c) and TAF (d) on inhibition of HIV in CD4+ T cells from blood (n = 6) and endometrium (n = 3). Data were normalized to % of HIV infection with respect to infected control without TFV or TAF pre-treated. The bar represents the mean and SEM. *p < 0.05.

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