Table 2 Minimum inhibitory concentration (µM) of thanatin and its analogs against EC: Escherichia coli; PA: Pseudomonas aeruginosa; SE: Salmonella enterica; KP: Klebsiella pneumoniae; SA: Staphylococcus aureus; BS: Bacillus subtilis; SP: Streptococcus pyogenes; EF: Enterococcus faecalis.
Peptide | Peptide Sequence | MIC (μM) | |||||||
|---|---|---|---|---|---|---|---|---|---|
Gram Negative | Gram Positive | ||||||||
EC | PA | SE | KP | SA | BS | SP | EF | ||
Thanatin | GSKKPVPIIYCNRRTGKCQRM | 0.5 | 1 | 1 | 1 | 1 | 2 | 0.5 | 0.5 |
Thanatin Y10M21AA | GSKKPVPIIACNRRTGKCQRA | 6 | 4 | 4 | 2 | 4 | 8 | 6 | 2 |
Thanatin R13R14AA | GSKKPVPIIYCNAATGKCQRM | >100 | >100 | >100 | >100 | >100 | >100 | >100 | >100 |
