Figure 1 | Scientific Reports

Figure 1

From: Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance

Figure 1

(A) Schematic showing location of guide targeting for each of CRISPRko, CRISPRi and CRISPRa. (B) Table and illustration of the constituents of the whole genome libraries and the nominated control groups. (C) Control groups behaviour. Top left show the mean log fold change between the input sample (plasmid baseline) and end point control (DMSO sample) for the groups of controls. Top right shows the gene-level mean data for each of the control genes. Bottom panels shows the individual guide-level data either segregated by group (left) or in a waterfall plot by value (right), indicating the partitioning of the positive control in the highly active group.

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