Figure 2 | Scientific Reports

Figure 2

From: Dual direction CRISPR transcriptional regulation screening uncovers gene networks driving drug resistance

Figure 2

(A) Screen design and schematic. (B) Screen results from CRISPRko resistance screen, plotting the magnitude of the effect (LogFC) against the MAGeCK RRA score (p-value) and highlighting eight key hits (DMSO vs. vemurafenib). (C) Results from the CRISPRi resistance screen with overlapping hits from the CRISPRko screen highlighted. (D) Log2 enrichment scores for each of the individual guides from hit genes in the CRISPRko screen. (E) Log2 enrichment scores for each of the individual guides from hit genes in the CRISPRi screen.

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