Figure 4
From: Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells
Econazole and cisplatin additively inhibited lung cancer cell line viability. (A) Econazole and cisplatin additively decreased the cell viability of H661 and A549 cells. The combination of econazole and cisplatin exhibited stronger inhibition than did any single drug. (B) Econazole and cisplatin additively induced apoptosis in H661 and A549 lung cancer cells. The combinations of econazole with cisplatin at the varying concentrations significantly induced more apoptosis in H661 and A549 cells than any single drug did, as measured by Annexin V/PI staining. (C) Econazole and cisplatin additively induced greater cleavage of PARP and Caspase-3 than any single drug did, as measured by Western blotting analysis. Normalized band intensities were added below cleaved PARP and Caspase-3.
