Table 1 Comparisons on US features between the benign group and the malignant group.

From: A Proposal to Stratify the Intermediate-Risk Thyroid Nodules According to the AACE/ACE/AME Guidelines with Ultrasound Features

Characteristics

Benign group (n = 902)

Malignant group (n = 98)

P

Gender

  

0.750

 Female

703(77.9)

75(76.5)

 

 Male

199(22.1)

23(23.5)

 

Age #1

52.8 ± 12.8

49.0 ± 14.0

0.007*

Maximum diameter #2

16(18)

10.5(21.25)

<0.001*

Maximum diameter

  

0.093

 ≤20mm

557 (61.8)

69(70.4)

 

 >20mm

345 (38.2)

29(29.6)

 

Margin

  

<0.001*

 Well defined

836(92.7)

79(80.6)

 

 Ill-defined

66(7.3)

19(19.4)

 

Echogenicity

  

0.006*

 Iso-echoic

254(28.2)

15(15.3)

 

 Slightly hypo-echoic

648(71.8)

83(84.7)

 

Location

  

0.412

 Left

406(45.0)

51(52.1)

 

 Right

484(53.6)

46(46.9)

 

 Isthmus

12(1.4)

1(1.0)

 

Component

  

0.894

 Solid

180(20.0)

19(19.4)

 

 Predominantly solid

722(80.0)

79(80.6)

 

Echo uniformity

  

0.721

 Uniform

315(34.9)

36(36.7)

 

 Non-uniform

587(65.1)

62(63.3)

 

Macro-calcification

  

0.022*

 Present

244(27.1)

16(16.3)

 

 Absent

658(72.9)

82(83.7)

 

Vascularity

  

0.075

 Type I

330(36.6)

37(37.8)

 

 Type II

246(27.3)

17(17.3)

 

 Type III

326(36.1)

44(44.9)

 

Indeterminate hyper-echoic spot

  

0.010*

 Present

13(1.4)

5(5.1)

 

 Absent

889(98.6)

93(94.9)

 
  1. Numbers in parentheses were percentages or inter-quartile range.
  2. #1Age was expressed as mean ± SD, #2maximum diameter was expressed as median (inter-quartile range), while other characteristics were expressed as number(percentage)
  3. *Statistically significant difference.